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acil çeviri
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Auxotrophy ( Gr. αὐξάνω "to increase"; τροφή
"nourishment") is the inability of an organism to
synthesize a particular organic compound
required for its growth (as defined by IUPAC ). An
auxotroph is an organism that displays this
characteristic; auxotrophic is the corresponding
adjective. Auxotrophy is the opposite of
prototrophy, which is characterized by the ability
to synthesize all the compounds needed for
growth.
The method of replica plating implemented by
Esther Lederberg included auxotrophs that were
temperature-sensitive; that is, their ability to
synthesize was temperature-dependent.
(Auxotrophs are usually not temperature-
dependent. They can also depend on other
factors.) Multiple auxotrophs can also coexist at
the same time, within the same organism.
In genetics , a strain is said to be auxotrophic if it
carries a mutation that renders it unable to
synthesize an essential compound. For example,
a yeast mutant with an inactivated uracil
synthesis pathway gene is a uracil auxotroph.
(E.g., if the yeast Orotidine 5'-phosphate
decarboxylase gene is inactivated, the resultant
strain is a uracil auxotroph.) Such a strain is
unable to synthesize uracil and will only be able
to grow if uracil can be taken up from the
environment. This is the opposite of a uracil
prototroph, or in this case a wild-type strain,
which can still grow in the absence of uracil.
Auxotrophic genetic markers are often used in
molecular genetics ; they were famously used in
Beadle and Tatum's Nobel prize -winning work
on the one gene-one enzyme hypothesis .
Researchers have used strains of E. coli
auxotrophic for specific amino acids to introduce
non-natural amino acid analogues into proteins.
For instance cells auxotrophic for the amino acid
phenylalanine can be grown in media
supplemented with an analogue such as para-
azido phenylalanine.
Many living things, including humans, are
auxotrophic for large classes of compounds
required for growth and must obtain these
compounds through diet (see vitamin , essential
nutrient , essential amino acid , essential fatty
acid ).
The complex pattern of evolution of vitamin
auxotrophy across the eukaryotic tree of life is
intimately connected with the interdependence
between organisms.
Auxotrophy ( Gr. αὐξάνω "to increase"; τροφή
"nourishment") is the inability of an organism to
synthesize a particular organic compound
required for its growth (as defined by IUPAC ). An
auxotroph is an organism that displays this
characteristic; auxotrophic is the corresponding
adjective. Auxotrophy is the opposite of
prototrophy, which is characterized by the ability
to synthesize all the compounds needed for
growth.
The method of replica plating implemented by
Esther Lederberg included auxotrophs that were
temperature-sensitive; that is, their ability to
synthesize was temperature-dependent.
(Auxotrophs are usually not temperature-
dependent. They can also depend on other
factors.) Multiple auxotrophs can also coexist at
the same time, within the same organism.
In genetics , a strain is said to be auxotrophic if it
carries a mutation that renders it unable to
synthesize an essential compound. For example,
a yeast mutant with an inactivated uracil
synthesis pathway gene is a uracil auxotroph.
(E.g., if the yeast Orotidine 5'-phosphate
decarboxylase gene is inactivated, the resultant
strain is a uracil auxotroph.) Such a strain is
unable to synthesize uracil and will only be able
to grow if uracil can be taken up from the
environment. This is the opposite of a uracil
prototroph, or in this case a wild-type strain,
which can still grow in the absence of uracil.
Auxotrophic genetic markers are often used in
molecular genetics ; they were famously used in
Beadle and Tatum's Nobel prize -winning work
on the one gene-one enzyme hypothesis .
Researchers have used strains of E. coli
auxotrophic for specific amino acids to introduce
non-natural amino acid analogues into proteins.
For instance cells auxotrophic for the amino acid
phenylalanine can be grown in media
supplemented with an analogue such as para-
azido phenylalanine.
Many living things, including humans, are
auxotrophic for large classes of compounds
required for growth and must obtain these
compounds through diet (see vitamin , essential
nutrient , essential amino acid , essential fatty
acid ).
The complex pattern of evolution of vitamin
auxotrophy across the eukaryotic tree of life is
intimately connected with the interdependence
between organisms.